Drug interactions
Imatinib + Tamsulosin
Severity: Moderate
Imatinib and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib is a moderate CYP3A4 inhibitor and may raise tamsulosin exposure. Higher tamsulosin levels can cause more orthostatic hypotension, dizziness and syncope.
What this interaction means in plain words
Imatinib and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Tamsulosin belongs to Genitourinary.
Why it happens
Imatinib inhibits CYP3A4-mediated metabolism of tamsulosin, reducing its clearance.
What to do
Counsel the patient about orthostatic symptoms and monitor blood pressure when imatinib is started. Reduce or stop tamsulosin if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Tamsulosin?
MediHelp rates the interaction as moderate. Imatinib and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib is a moderate CYP3A4 inhibitor and may raise tamsulosin exposure. Higher tamsulosin levels can cause more orthostatic hypotension, dizziness and syncope.
How serious is the interaction between Imatinib and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about orthostatic symptoms and monitor blood pressure when imatinib is started. Reduce or stop tamsulosin if symptomatic hypotension develops.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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