Drug interactions
Imatinib + Tinidazole
Severity: Minor
Imatinib and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib is a moderate CYP3A4 inhibitor and may increase tinidazole concentrations. Tinidazole is a short-course agent with a wide margin, so the effect is usually modest, though gastrointestinal and neurological adverse effects could be more noticeable.
What this interaction means in plain words
Imatinib and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imatinib belongs to Oncology; Tinidazole belongs to Anti Parasitic.
Why it happens
Imatinib inhibits CYP3A4, which contributes to tinidazole metabolism.
What to do
No routine dose change is needed; watch for nausea, dizziness or other neurological symptoms during the tinidazole course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Tinidazole?
MediHelp rates the interaction as minor. Imatinib and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib is a moderate CYP3A4 inhibitor and may increase tinidazole concentrations. Tinidazole is a short-course agent with a wide margin, so the effect is usually modest, though gastrointestinal and neurological adverse effects could be more noticeable.
How serious is the interaction between Imatinib and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for nausea, dizziness or other neurological symptoms during the tinidazole course.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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