Drug interactions
Imatinib + Umeclidinium-vilanterol
Severity: Minor
Imatinib and Umeclidinium-vilanterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib is a moderate CYP3A4 inhibitor and may modestly raise vilanterol exposure, since vilanterol is a CYP3A4 substrate. Because the inhaled dose is low, the effect is usually small but could increase beta-agonist adverse effects.
What this interaction means in plain words
Imatinib and Umeclidinium-vilanterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imatinib belongs to Oncology; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Inhibition of CYP3A4-mediated metabolism of vilanterol, raising its systemic exposure.
What to do
No dose change is usually needed. Watch for tachycardia, tremor or palpitations and reassess if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Umeclidinium-vilanterol?
MediHelp rates the interaction as minor. Imatinib and Umeclidinium-vilanterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib is a moderate CYP3A4 inhibitor and may modestly raise vilanterol exposure, since vilanterol is a CYP3A4 substrate. Because the inhaled dose is low, the effect is usually small but could increase beta-agonist adverse effects.
How serious is the interaction between Imatinib and Umeclidinium-vilanterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Watch for tachycardia, tremor or palpitations and reassess if they occur.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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