Drug interactions
Imatinib + Voxelotor
Severity: Moderate
Imatinib and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor is a CYP3A4 inhibitor and may increase imatinib concentrations. Higher imatinib exposure may worsen edema, cytopenias and hepatotoxicity.
What this interaction means in plain words
Imatinib and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4-mediated metabolism of imatinib.
What to do
Monitor blood counts, liver tests and fluid retention. Reduce the imatinib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Imatinib with Voxelotor?
MediHelp rates the interaction as moderate. Imatinib and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor is a CYP3A4 inhibitor and may increase imatinib concentrations. Higher imatinib exposure may worsen edema, cytopenias and hepatotoxicity.
How serious is the interaction between Imatinib and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, liver tests and fluid retention. Reduce the imatinib dose if toxicity occurs.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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