Drug interactions
Imatinib + Zidovudine
Severity: Moderate
Imatinib and Zidovudine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib frequently causes neutropenia, thrombocytopenia and anemia, which may be compounded by zidovudine. The combination can result in more pronounced cytopenias.
What this interaction means in plain words
Imatinib and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Zidovudine belongs to Anti Virals.
Why it happens
Additive myelosuppression through pharmacodynamic synergism.
What to do
Monitor complete blood counts frequently, and adjust imatinib dosing or interrupt treatment per labeling if severe cytopenias occur. Consider a non-zidovudine regimen if cytopenias persist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Zidovudine?
MediHelp rates the interaction as moderate. Imatinib and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib frequently causes neutropenia, thrombocytopenia and anemia, which may be compounded by zidovudine. The combination can result in more pronounced cytopenias.
How serious is the interaction between Imatinib and Zidovudine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently, and adjust imatinib dosing or interrupt treatment per labeling if severe cytopenias occur. Consider a non-zidovudine regimen if cytopenias persist.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
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