Drug interactions
Imidapril + Insulin glulisine
Severity: Moderate
Imidapril and Insulin glulisine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors such as imidapril can enhance insulin sensitivity and occasionally cause hypoglycemia in patients on insulin. The effect is usually modest but may be seen after starting the ACE inhibitor.
What this interaction means in plain words
Imidapril and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imidapril belongs to Cardiovascular; Insulin glulisine belongs to Endocrine.
Why it happens
ACE inhibition may increase insulin sensitivity, possibly via increased bradykinin and improved glucose uptake, adding to the effect of insulin.
What to do
Monitor blood glucose when imidapril is started or the dose is changed, and reduce insulin if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glulisine
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Imidapril with Insulin glulisine?
MediHelp rates the interaction as moderate. Imidapril and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors such as imidapril can enhance insulin sensitivity and occasionally cause hypoglycemia in patients on insulin. The effect is usually modest but may be seen after starting the ACE inhibitor.
How serious is the interaction between Imidapril and Insulin glulisine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when imidapril is started or the dose is changed, and reduce insulin if hypoglycemia develops.
What other medicines interact with Insulin glulisine?
MediHelp also lists interactions of Insulin glulisine with, for example, Alogliptin-pioglitazone, Ethanol, Pentamidine. The full list is on the Insulin glulisine page.
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