Drug interactions
Imidapril + Meclofenamic acid
Severity: Moderate
Imidapril and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the blood pressure lowering effect of ACE inhibitors and, together, may impair renal function, particularly in elderly, dehydrated or renally impaired patients. Hyperkalemia may also occur.
What this interaction means in plain words
Imidapril and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imidapril belongs to Cardiovascular; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory prostaglandins reduces ACE inhibitor antihypertensive effect and lowers glomerular filtration.
What to do
Monitor blood pressure, serum creatinine and potassium, and keep patients hydrated. Use the lowest effective NSAID dose for the shortest duration or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Imidapril with Meclofenamic acid?
MediHelp rates the interaction as moderate. Imidapril and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the blood pressure lowering effect of ACE inhibitors and, together, may impair renal function, particularly in elderly, dehydrated or renally impaired patients. Hyperkalemia may also occur.
How serious is the interaction between Imidapril and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and keep patients hydrated. Use the lowest effective NSAID dose for the shortest duration or choose an alternative analgesic.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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