Drug interactions
Imidapril + Metformin-repaglinide
Severity: Moderate
Imidapril and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. Reduced renal function on an ACE inhibitor could also raise metformin levels and the risk of lactic acidosis.
What this interaction means in plain words
Imidapril and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imidapril belongs to Cardiovascular; Metformin-repaglinide belongs to Endocrine.
Why it happens
Additive glucose-lowering via improved insulin sensitivity, plus possible reduced renal metformin clearance.
What to do
Monitor blood glucose after starting or changing the ACE inhibitor. Check renal function periodically and review metformin dosing if eGFR falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Imidapril with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Imidapril and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. Reduced renal function on an ACE inhibitor could also raise metformin levels and the risk of lactic acidosis.
How serious is the interaction between Imidapril and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing the ACE inhibitor. Check renal function periodically and review metformin dosing if eGFR falls.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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