Drug interactions
Imidapril + Naproxen
Severity: Moderate
Imidapril and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can weaken the antihypertensive effect of ACE inhibitors such as imidapril. Together they increase the risk of acute kidney injury and hyperkalemia, particularly in older, dehydrated or renally impaired patients.
What this interaction means in plain words
Imidapril and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imidapril belongs to Cardiovascular; Naproxen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory prostaglandins reduces renal perfusion and opposes ACE inhibitor effects on blood pressure and glomerular hemodynamics.
What to do
Monitor blood pressure, creatinine and potassium, especially in the first weeks of combined therapy. Maintain hydration and prefer a non-NSAID analgesic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Imidapril with Naproxen?
MediHelp rates the interaction as moderate. Imidapril and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can weaken the antihypertensive effect of ACE inhibitors such as imidapril. Together they increase the risk of acute kidney injury and hyperkalemia, particularly in older, dehydrated or renally impaired patients.
How serious is the interaction between Imidapril and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium, especially in the first weeks of combined therapy. Maintain hydration and prefer a non-NSAID analgesic in high-risk patients.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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