Drug interactions
Imidapril + Promethazine
Severity: Minor
Imidapril and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promethazine can cause orthostatic hypotension through alpha-adrenergic blockade, which may add to the blood pressure lowering of imidapril. The effect is usually small but may matter in older or volume-depleted patients.
What this interaction means in plain words
Imidapril and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imidapril belongs to Cardiovascular; Promethazine belongs to Respiratory.
Why it happens
Additive hypotensive effect from alpha-blockade by promethazine and ACE inhibition.
What to do
Monitor blood pressure and ask about dizziness when promethazine is started. Advise patients to rise slowly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Imidapril with Promethazine?
MediHelp rates the interaction as minor. Imidapril and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Promethazine can cause orthostatic hypotension through alpha-adrenergic blockade, which may add to the blood pressure lowering of imidapril. The effect is usually small but may matter in older or volume-depleted patients.
How serious is the interaction between Imidapril and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and ask about dizziness when promethazine is started. Advise patients to rise slowly.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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