Drug interactions
Imidapril + Sulphasalazine
Severity: Minor
Imidapril and Sulphasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine is not an NSAID with meaningful prostaglandin inhibition, so loss of antihypertensive effect is unlikely. ACE inhibitors and sulfasalazine can each rarely cause blood dyscrasias or renal effects.
What this interaction means in plain words
Imidapril and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imidapril belongs to Cardiovascular; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Theoretical prostaglandin antagonism; not established for sulfasalazine.
What to do
No specific action required. Monitor blood pressure and renal function routinely.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Acetazolamide + Sulphasalazine Moderate
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Imidapril with Sulphasalazine?
MediHelp rates the interaction as minor. Imidapril and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine is not an NSAID with meaningful prostaglandin inhibition, so loss of antihypertensive effect is unlikely. ACE inhibitors and sulfasalazine can each rarely cause blood dyscrasias or renal effects.
How serious is the interaction between Imidapril and Sulphasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action required. Monitor blood pressure and renal function routinely.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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