Drug interactions
Imipramine + Indacaterol-glycopyrronium
Severity: Moderate
Imipramine and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can prolong the QT interval and may heighten cardiovascular effects of beta-2 agonists. Imipramine also has strong anticholinergic activity that adds to glycopyrronium, raising the risk of dry mouth, urinary retention, constipation and tachycardia.
What this interaction means in plain words
Imipramine and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive QT prolongation and adrenergic cardiovascular effects, plus additive anticholinergic effects.
What to do
Monitor ECG and heart rate in patients with cardiac risk factors, and watch for anticholinergic effects such as urinary retention. Consider an alternative antidepressant if arrhythmia risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Imipramine and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can prolong the QT interval and may heighten cardiovascular effects of beta-2 agonists. Imipramine also has strong anticholinergic activity that adds to glycopyrronium, raising the risk of dry mouth, urinary retention, constipation and tachycardia.
How serious is the interaction between Imipramine and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate in patients with cardiac risk factors, and watch for anticholinergic effects such as urinary retention. Consider an alternative antidepressant if arrhythmia risk is high.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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