Drug interactions
Imipramine + Letermovir
Severity: Moderate
Imipramine and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir can raise concentrations of CYP3A substrates through moderate CYP3A inhibition. Imipramine is partly metabolized by CYP3A4, so exposure may rise modestly, with greater anticholinergic, sedative and cardiac effects.
What this interaction means in plain words
Imipramine and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Letermovir belongs to Anti Virals.
Why it happens
Letermovir inhibits CYP3A4, reducing imipramine clearance.
What to do
Monitor for tricyclic adverse effects and ECG changes during co-treatment; reduce imipramine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Imipramine with Letermovir?
MediHelp rates the interaction as moderate. Imipramine and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir can raise concentrations of CYP3A substrates through moderate CYP3A inhibition. Imipramine is partly metabolized by CYP3A4, so exposure may rise modestly, with greater anticholinergic, sedative and cardiac effects.
How serious is the interaction between Imipramine and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and ECG changes during co-treatment; reduce imipramine dose if toxicity appears.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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