Drug interactions
Imipramine + Lonafarnib
Severity: Major
Imipramine and Lonafarnib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib can raise exposure to imipramine, which is partly cleared by CYP2C19 and CYP3A4. Higher tricyclic levels increase risks of anticholinergic effects, sedation, seizures and cardiac conduction abnormalities.
What this interaction means in plain words
Imipramine and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Imipramine belongs to Central Nervous System; Lonafarnib belongs to Miscellaneous.
Why it happens
Lonafarnib inhibits CYP3A4 and CYP2C19, reducing imipramine metabolism.
What to do
Avoid if an alternative exists. If used together, reduce the imipramine dose, monitor for toxicity and consider tricyclic levels and ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Imipramine with Lonafarnib?
MediHelp rates the interaction as major. Imipramine and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lonafarnib can raise exposure to imipramine, which is partly cleared by CYP2C19 and CYP3A4. Higher tricyclic levels increase risks of anticholinergic effects, sedation, seizures and cardiac conduction abnormalities.
How serious is the interaction between Imipramine and Lonafarnib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative exists. If used together, reduce the imipramine dose, monitor for toxicity and consider tricyclic levels and ECG.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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