Drug interactions
Imipramine + Lurasidone
Severity: Moderate
Imipramine and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and orthostatic hypotension, so combined use increases the chance of dizziness, falls and impaired psychomotor performance. Imipramine may also contribute to QT effects.
What this interaction means in plain words
Imipramine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Additive CNS depressant and alpha-adrenergic blocking effects.
What to do
Monitor blood pressure including orthostatic readings and level of sedation, especially at initiation and after dose increases. Counsel patients about rising slowly and avoiding driving until response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Imipramine with Lurasidone?
MediHelp rates the interaction as moderate. Imipramine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation and orthostatic hypotension, so combined use increases the chance of dizziness, falls and impaired psychomotor performance. Imipramine may also contribute to QT effects.
How serious is the interaction between Imipramine and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including orthostatic readings and level of sedation, especially at initiation and after dose increases. Counsel patients about rising slowly and avoiding driving until response is known.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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