Drug interactions
Imipramine + Mirabegron
Severity: Moderate
Imipramine and Mirabegron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine and its active metabolite desipramine depend on CYP2D6 for clearance, so mirabegron can increase tricyclic exposure. This may cause anticholinergic effects, tachycardia and conduction abnormalities.
What this interaction means in plain words
Imipramine and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Mirabegron belongs to Genitourinary.
Why it happens
Mirabegron inhibits CYP2D6, reducing clearance of imipramine and desipramine.
What to do
Monitor ECG and anticholinergic symptoms, and consider tricyclic plasma levels. Reduce the imipramine dose if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Mirabegron?
MediHelp rates the interaction as moderate. Imipramine and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine and its active metabolite desipramine depend on CYP2D6 for clearance, so mirabegron can increase tricyclic exposure. This may cause anticholinergic effects, tachycardia and conduction abnormalities.
How serious is the interaction between Imipramine and Mirabegron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and anticholinergic symptoms, and consider tricyclic plasma levels. Reduce the imipramine dose if toxicity emerges.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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