Drug interactions
Imipramine + Nabilone
Severity: Moderate
Imipramine and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause CNS depression, so the combination can increase drowsiness and impair psychomotor performance. Both can also cause tachycardia and orthostatic hypotension, and imipramine adds anticholinergic effects.
What this interaction means in plain words
Imipramine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression, with additive tachycardia and orthostatic hypotension.
What to do
Use low starting doses and monitor sedation, heart rate and blood pressure. Advise patients to avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Nabilone?
MediHelp rates the interaction as moderate. Imipramine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause CNS depression, so the combination can increase drowsiness and impair psychomotor performance. Both can also cause tachycardia and orthostatic hypotension, and imipramine adds anticholinergic effects.
How serious is the interaction between Imipramine and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use low starting doses and monitor sedation, heart rate and blood pressure. Advise patients to avoid driving until the response is known.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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