Drug interactions
Imipramine + Papaverine
Severity: Minor
Imipramine and Papaverine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No well-established clinically meaningful interaction exists between these drugs. Additive sedation or hypotension is only a theoretical concern.
What this interaction means in plain words
Imipramine and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imipramine belongs to Central Nervous System; Papaverine belongs to Cardiovascular.
Why it happens
Possible additive vasodilatory and CNS effects; mechanism not firmly established.
What to do
Monitor blood pressure and sedation at initiation. No dose adjustment is usually necessary.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
Frequently asked questions
Can I take Imipramine with Papaverine?
MediHelp rates the interaction as minor. Imipramine and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No well-established clinically meaningful interaction exists between these drugs. Additive sedation or hypotension is only a theoretical concern.
How serious is the interaction between Imipramine and Papaverine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and sedation at initiation. No dose adjustment is usually necessary.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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