Drug interactions
Imipramine + Peginterferon alfa 2b
Severity: Minor
Imipramine and Peginterferon alfa 2b: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peginterferon alfa 2b may modestly alter CYP2D6 metabolism of imipramine, with an unpredictable direction. Any change is likely small, but tricyclic toxicity could emerge in susceptible patients.
What this interaction means in plain words
Imipramine and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imipramine belongs to Central Nervous System; Peginterferon alfa 2b belongs to Anti Virals.
Why it happens
Possible interferon modulation of CYP2D6; not firmly established.
What to do
Monitor for anticholinergic, sedative and cardiac effects and for clinical response. Adjust the imipramine dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Peginterferon alfa 2b
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Peginterferon alfa 2b?
MediHelp rates the interaction as minor. Imipramine and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Peginterferon alfa 2b may modestly alter CYP2D6 metabolism of imipramine, with an unpredictable direction. Any change is likely small, but tricyclic toxicity could emerge in susceptible patients.
How serious is the interaction between Imipramine and Peginterferon alfa 2b?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic, sedative and cardiac effects and for clinical response. Adjust the imipramine dose as needed.
What other medicines interact with Peginterferon alfa 2b?
MediHelp also lists interactions of Peginterferon alfa 2b with, for example, Aldesleukin, Deferiprone, Pexidartinib. The full list is on the Peginterferon alfa 2b page.
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