Drug interactions
Imipramine + Phentermine
Severity: Moderate
Imipramine and Phentermine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentermine releases norepinephrine, and tricyclics can alter the response to indirectly acting sympathomimetics, resulting in hypertension, tachycardia or arrhythmia. Serotonergic overlap is possible but less well defined.
What this interaction means in plain words
Imipramine and Phentermine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Phentermine belongs to Central Nervous System.
Why it happens
Additive noradrenergic effects with tricyclic interference in sympathomimetic uptake.
What to do
Monitor blood pressure, heart rate and mood when combining. Consider an alternative weight-loss option in patients with cardiovascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Phentermine
- Isocarboxazid + Phentermine Contraindicated
- Linezolid + Phentermine Contraindicated
- Phenelzine + Phentermine Contraindicated
- Phentermine + Procarbazine Contraindicated
- Phentermine + Rasagiline Contraindicated
- Phentermine + Selegiline Contraindicated
Frequently asked questions
Can I take Imipramine with Phentermine?
MediHelp rates the interaction as moderate. Imipramine and Phentermine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phentermine releases norepinephrine, and tricyclics can alter the response to indirectly acting sympathomimetics, resulting in hypertension, tachycardia or arrhythmia. Serotonergic overlap is possible but less well defined.
How serious is the interaction between Imipramine and Phentermine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and mood when combining. Consider an alternative weight-loss option in patients with cardiovascular disease.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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