Drug interactions
Imipramine + Selinexor
Severity: Moderate
Imipramine and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and other neurological effects, and imipramine's sedative and anticholinergic effects may add to these. The result may be falls, cognitive impairment and reduced treatment tolerability.
What this interaction means in plain words
Imipramine and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Selinexor belongs to Oncology.
Why it happens
Additive CNS effects; no pharmacokinetic mechanism is established.
What to do
Monitor for dizziness, confusion and sedation and counsel patients on fall precautions. Reduce the imipramine dose or consider alternatives if neurological symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Imipramine with Selinexor?
MediHelp rates the interaction as moderate. Imipramine and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and other neurological effects, and imipramine's sedative and anticholinergic effects may add to these. The result may be falls, cognitive impairment and reduced treatment tolerability.
How serious is the interaction between Imipramine and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and sedation and counsel patients on fall precautions. Reduce the imipramine dose or consider alternatives if neurological symptoms develop.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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