Drug interactions
Imipramine + Solifenacin
Severity: Moderate
Imipramine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine has strong anticholinergic properties and can prolong QT/QRS, so adding solifenacin increases antimuscarinic burden and may add to QT risk. This can cause urinary retention, constipation, dry mouth, confusion, tachycardia and arrhythmia, especially in older patients.
What this interaction means in plain words
Imipramine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects and additive cardiac conduction/QT prolongation.
What to do
Monitor for anticholinergic toxicity and urinary retention, and obtain an ECG in patients with cardiac disease or other QT-prolonging drugs. Consider a non-anticholinergic bladder agent such as mirabegron where appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Solifenacin?
MediHelp rates the interaction as moderate. Imipramine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine has strong anticholinergic properties and can prolong QT/QRS, so adding solifenacin increases antimuscarinic burden and may add to QT risk. This can cause urinary retention, constipation, dry mouth, confusion, tachycardia and arrhythmia, especially in older patients.
How serious is the interaction between Imipramine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and urinary retention, and obtain an ECG in patients with cardiac disease or other QT-prolonging drugs. Consider a non-anticholinergic bladder agent such as mirabegron where appropriate.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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