Drug interactions
Imipramine + Tipranavir
Severity: Moderate
Imipramine and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir given with ritonavir may increase imipramine concentrations, raising the risk of anticholinergic effects, sedation, arrhythmia and seizures. Ritonavir-boosted regimens inhibit several CYP enzymes involved in tricyclic metabolism.
What this interaction means in plain words
Imipramine and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Tipranavir belongs to Anti Virals.
Why it happens
Inhibition of CYP2D6 (and other CYP pathways) by the tipranavir/ritonavir combination reduces imipramine clearance.
What to do
Consider starting imipramine at a lower dose and titrate by response. Monitor ECG and tricyclic levels if available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Imipramine with Tipranavir?
MediHelp rates the interaction as moderate. Imipramine and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir given with ritonavir may increase imipramine concentrations, raising the risk of anticholinergic effects, sedation, arrhythmia and seizures. Ritonavir-boosted regimens inhibit several CYP enzymes involved in tricyclic metabolism.
How serious is the interaction between Imipramine and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider starting imipramine at a lower dose and titrate by response. Monitor ECG and tricyclic levels if available.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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