Drug interactions
Indacaterol + Pimozide
Severity: Major
Indacaterol and Pimozide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide markedly prolongs the QT interval and carries a notable torsades risk. Indacaterol can add to arrhythmic risk through cardiac stimulation and hypokalemia.
What this interaction means in plain words
Indacaterol and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol belongs to Respiratory; Pimozide belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with beta-2 agonist-induced hypokalemia increasing proarrhythmic susceptibility.
What to do
Obtain a baseline ECG and monitor QTc regularly, correcting potassium and magnesium. Consider an alternative if QTc becomes prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Indacaterol with Pimozide?
MediHelp rates the interaction as major. Indacaterol and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pimozide markedly prolongs the QT interval and carries a notable torsades risk. Indacaterol can add to arrhythmic risk through cardiac stimulation and hypokalemia.
How serious is the interaction between Indacaterol and Pimozide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc regularly, correcting potassium and magnesium. Consider an alternative if QTc becomes prolonged.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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