Drug interactions
Indacaterol + Pindolol
Severity: Major
Indacaterol and Pindolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pindolol is a non-selective beta-blocker with intrinsic sympathomimetic activity that can antagonize indacaterol and trigger bronchospasm in patients with reactive airways. Bronchodilator benefit may be reduced.
What this interaction means in plain words
Indacaterol and Pindolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors, blocking bronchodilation.
What to do
Avoid pindolol in patients with COPD or asthma who need indacaterol. If a beta-blocker is required, use a cardioselective agent and monitor lung function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Frequently asked questions
Can I take Indacaterol with Pindolol?
MediHelp rates the interaction as major. Indacaterol and Pindolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pindolol is a non-selective beta-blocker with intrinsic sympathomimetic activity that can antagonize indacaterol and trigger bronchospasm in patients with reactive airways. Bronchodilator benefit may be reduced.
How serious is the interaction between Indacaterol and Pindolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid pindolol in patients with COPD or asthma who need indacaterol. If a beta-blocker is required, use a cardioselective agent and monitor lung function.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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