Drug interactions
Indacaterol + Propranolol
Severity: Major
Indacaterol and Propranolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol is a nonselective beta-blocker that antagonizes indacaterol's bronchodilation and can provoke severe bronchospasm in patients with airway disease. The two drugs effectively oppose each other.
What this interaction means in plain words
Indacaterol and Propranolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol belongs to Respiratory; Propranolol belongs to Cardiovascular.
Why it happens
Competitive antagonism at beta-2 receptors by a nonselective beta-blocker.
What to do
Avoid propranolol in patients with COPD or asthma. If a beta-blocker is essential, use a cardioselective agent at the lowest dose with respiratory monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Indacaterol with Propranolol?
MediHelp rates the interaction as major. Indacaterol and Propranolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Propranolol is a nonselective beta-blocker that antagonizes indacaterol's bronchodilation and can provoke severe bronchospasm in patients with airway disease. The two drugs effectively oppose each other.
How serious is the interaction between Indacaterol and Propranolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid propranolol in patients with COPD or asthma. If a beta-blocker is essential, use a cardioselective agent at the lowest dose with respiratory monitoring.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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