Drug interactions
Indacaterol + Protriptyline
Severity: Major
Indacaterol and Protriptyline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of beta-2 agonists and prolong the QT interval. The combination may increase tachycardia and the risk of ventricular arrhythmias.
What this interaction means in plain words
Indacaterol and Protriptyline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation, and tricyclic noradrenaline reuptake inhibition potentiates adrenergic cardiovascular effects.
What to do
Avoid the combination if an alternative antidepressant is feasible. If used together, monitor ECG, heart rate and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Frequently asked questions
Can I take Indacaterol with Protriptyline?
MediHelp rates the interaction as major. Indacaterol and Protriptyline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants can potentiate the cardiovascular effects of beta-2 agonists and prolong the QT interval. The combination may increase tachycardia and the risk of ventricular arrhythmias.
How serious is the interaction between Indacaterol and Protriptyline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative antidepressant is feasible. If used together, monitor ECG, heart rate and potassium.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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