Drug interactions
Indacaterol + Saquinavir
Severity: Moderate
Indacaterol and Saquinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir inhibits CYP3A4 and P-glycoprotein and may increase indacaterol exposure, with greater beta-adrenergic effects. Saquinavir also prolongs QT and PR intervals, adding to arrhythmia risk.
What this interaction means in plain words
Indacaterol and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4/P-gp clearance of indacaterol plus additive QT prolongation.
What to do
Obtain a baseline ECG and monitor heart rate, potassium and ECG during co-use. Avoid other QT-prolonging agents when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Frequently asked questions
Can I take Indacaterol with Saquinavir?
MediHelp rates the interaction as moderate. Indacaterol and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Saquinavir inhibits CYP3A4 and P-glycoprotein and may increase indacaterol exposure, with greater beta-adrenergic effects. Saquinavir also prolongs QT and PR intervals, adding to arrhythmia risk.
How serious is the interaction between Indacaterol and Saquinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor heart rate, potassium and ECG during co-use. Avoid other QT-prolonging agents when possible.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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