Drug interactions
Indacaterol + Umeclidinium bromide / vilanterol inhaled
Severity: Major
Indacaterol and Umeclidinium bromide / vilanterol inhaled: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol and vilanterol are both long-acting beta2-agonists, so combining them duplicates therapy and increases adrenergic effects such as tachycardia, tremor, hypokalemia and arrhythmia. It offers no added benefit.
What this interaction means in plain words
Indacaterol and Umeclidinium bromide / vilanterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive beta2-adrenergic agonism from duplicate long-acting beta-agonists.
What to do
Do not use two LABA-containing products together; select a single regimen. Monitor heart rate and potassium if overlap has occurred.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Frequently asked questions
Can I take Indacaterol with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as major. Indacaterol and Umeclidinium bromide / vilanterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indacaterol and vilanterol are both long-acting beta2-agonists, so combining them duplicates therapy and increases adrenergic effects such as tachycardia, tremor, hypokalemia and arrhythmia. It offers no added benefit.
How serious is the interaction between Indacaterol and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use two LABA-containing products together; select a single regimen. Monitor heart rate and potassium if overlap has occurred.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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