Drug interactions
Indacaterol-glycopyrronium + Isocarboxazid
Severity: Major
Indacaterol-glycopyrronium and Isocarboxazid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can potentiate the cardiovascular effects of beta-2 agonists, leading to palpitations, hypertension or arrhythmias. QT prolongation concerns are also described with this class.
What this interaction means in plain words
Indacaterol-glycopyrronium and Isocarboxazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol-glycopyrronium belongs to Respiratory; Isocarboxazid belongs to Central Nervous System.
Why it happens
MAO inhibition enhances sympathomimetic cardiovascular effects, with possible additive QT effects.
What to do
Use only if necessary and monitor blood pressure, heart rate and ECG, particularly after initiation. Consider an alternative bronchodilator if cardiovascular symptoms occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Indacaterol-glycopyrronium and Isocarboxazid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Indacaterol-glycopyrronium
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Isocarboxazid?
MediHelp rates the interaction as major. Indacaterol-glycopyrronium and Isocarboxazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. MAO inhibitors can potentiate the cardiovascular effects of beta-2 agonists, leading to palpitations, hypertension or arrhythmias. QT prolongation concerns are also described with this class.
How serious is the interaction between Indacaterol-glycopyrronium and Isocarboxazid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only if necessary and monitor blood pressure, heart rate and ECG, particularly after initiation. Consider an alternative bronchodilator if cardiovascular symptoms occur.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
