Drug interactions
Indacaterol-glycopyrronium + Ivosidenib
Severity: Moderate
Indacaterol-glycopyrronium and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib prolongs the QT interval and its labeling advises avoiding other QT-prolonging drugs. Indacaterol may contribute modestly through beta-adrenergic effects and potassium lowering.
What this interaction means in plain words
Indacaterol-glycopyrronium and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Ivosidenib belongs to Oncology.
Why it happens
Additive QT prolongation, with possible beta-agonist-induced hypokalemia.
What to do
Monitor ECG and electrolytes at baseline and regularly during therapy, correcting potassium and magnesium. Prefer a non-QT-prolonging bronchodilator regimen where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Ivosidenib?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib prolongs the QT interval and its labeling advises avoiding other QT-prolonging drugs. Indacaterol may contribute modestly through beta-adrenergic effects and potassium lowering.
How serious is the interaction between Indacaterol-glycopyrronium and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and regularly during therapy, correcting potassium and magnesium. Prefer a non-QT-prolonging bronchodilator regimen where feasible.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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