Drug interactions
Indacaterol-glycopyrronium + Ketoconazole
Severity: Minor
Indacaterol-glycopyrronium and Ketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole inhibits CYP3A4 and P-glycoprotein, which raises systemic indacaterol exposure. The increase is modest at usual doses and was not considered to need adjustment, but beta-agonist adverse effects could be enhanced.
What this interaction means in plain words
Indacaterol-glycopyrronium and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indacaterol-glycopyrronium belongs to Respiratory; Ketoconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 and P-gp reduces indacaterol clearance.
What to do
No dose adjustment is generally needed at standard doses. Be aware of tremor, palpitations or tachycardia during coadministration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Ketoconazole?
MediHelp rates the interaction as minor. Indacaterol-glycopyrronium and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole inhibits CYP3A4 and P-glycoprotein, which raises systemic indacaterol exposure. The increase is modest at usual doses and was not considered to need adjustment, but beta-agonist adverse effects could be enhanced.
How serious is the interaction between Indacaterol-glycopyrronium and Ketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed at standard doses. Be aware of tremor, palpitations or tachycardia during coadministration.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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