Drug interactions
Indacaterol-glycopyrronium + Lefamulin
Severity: Moderate
Indacaterol-glycopyrronium and Lefamulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin can prolong the QT interval, and beta-agonists such as indacaterol may add to the risk. The combination may increase the chance of ventricular arrhythmia, especially with hypokalemia or cardiac disease.
What this interaction means in plain words
Indacaterol-glycopyrronium and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Lefamulin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation, with beta-agonist-related hypokalemia as a possible contributor.
What to do
Check ECG and correct electrolytes before using together, and monitor during the short antibiotic course. Choose another antibiotic in patients with baseline QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Lefamulin?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lefamulin can prolong the QT interval, and beta-agonists such as indacaterol may add to the risk. The combination may increase the chance of ventricular arrhythmia, especially with hypokalemia or cardiac disease.
How serious is the interaction between Indacaterol-glycopyrronium and Lefamulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct electrolytes before using together, and monitor during the short antibiotic course. Choose another antibiotic in patients with baseline QT prolongation.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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