Drug interactions
Indacaterol-glycopyrronium + Methadone
Severity: Moderate
Indacaterol-glycopyrronium and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methadone prolongs the QT interval in a dose-related manner, and indacaterol may add to arrhythmic risk through QT effects and hypokalemia. Torsades de pointes is the main concern.
What this interaction means in plain words
Indacaterol-glycopyrronium and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Methadone belongs to Musculoskeletal.
Why it happens
Additive QT prolongation with beta-agonist-induced hypokalemia.
What to do
Obtain ECG monitoring in patients on higher methadone doses or with other risk factors. Maintain normal potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Methadone?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methadone prolongs the QT interval in a dose-related manner, and indacaterol may add to arrhythmic risk through QT effects and hypokalemia. Torsades de pointes is the main concern.
How serious is the interaction between Indacaterol-glycopyrronium and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECG monitoring in patients on higher methadone doses or with other risk factors. Maintain normal potassium and magnesium.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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