Drug interactions
Indacaterol-glycopyrronium + Nelfinavir
Severity: Minor
Indacaterol-glycopyrronium and Nelfinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and P-glycoprotein, which can raise systemic exposure to indacaterol. Higher exposure may increase beta-agonist effects such as tachycardia, tremor and hypokalemia. The effect is modest at the usual inhaled dose.
What this interaction means in plain words
Indacaterol-glycopyrronium and Nelfinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indacaterol-glycopyrronium belongs to Respiratory; Nelfinavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by nelfinavir reduces indacaterol clearance.
What to do
No dose change is generally needed at the standard dose. Monitor heart rate, tremor and potassium if symptoms of beta-agonist excess appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Indacaterol-glycopyrronium and Nelfinavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Indacaterol-glycopyrronium
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Nelfinavir?
MediHelp rates the interaction as minor. Indacaterol-glycopyrronium and Nelfinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nelfinavir inhibits CYP3A4 and P-glycoprotein, which can raise systemic exposure to indacaterol. Higher exposure may increase beta-agonist effects such as tachycardia, tremor and hypokalemia. The effect is modest at the usual inhaled dose.
How serious is the interaction between Indacaterol-glycopyrronium and Nelfinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed at the standard dose. Monitor heart rate, tremor and potassium if symptoms of beta-agonist excess appear.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
