Drug interactions
Indacaterol-glycopyrronium + Ofloxacin
Severity: Moderate
Indacaterol-glycopyrronium and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofloxacin can prolong the QT interval, and indacaterol may add to this effect and lower potassium. The combination may increase the risk of torsades de pointes in susceptible patients.
What this interaction means in plain words
Indacaterol-glycopyrronium and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Ofloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation, with beta-2 agonist-induced hypokalemia potentially increasing arrhythmic risk.
What to do
Check baseline QTc and electrolytes in patients with cardiac disease or other QT-prolonging drugs. Correct hypokalemia and consider an alternative antibiotic if QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Ofloxacin?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofloxacin can prolong the QT interval, and indacaterol may add to this effect and lower potassium. The combination may increase the risk of torsades de pointes in susceptible patients.
How serious is the interaction between Indacaterol-glycopyrronium and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline QTc and electrolytes in patients with cardiac disease or other QT-prolonging drugs. Correct hypokalemia and consider an alternative antibiotic if QTc becomes prolonged.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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