Drug interactions
Indacaterol-glycopyrronium + Oxybutynin
Severity: Moderate
Indacaterol-glycopyrronium and Oxybutynin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybutynin is a systemic antimuscarinic and adds to the anticholinergic effect of inhaled glycopyrronium. This can increase dry mouth, constipation, urinary retention, blurred vision and confusion, particularly in older adults.
What this interaction means in plain words
Indacaterol-glycopyrronium and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Oxybutynin belongs to Genitourinary.
Why it happens
Additive antimuscarinic receptor blockade.
What to do
Monitor for anticholinergic adverse effects and urinary retention, and use the lowest effective oxybutynin dose. Consider a non-anticholinergic bladder option in older or susceptible patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Oxybutynin
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Oxybutynin?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxybutynin is a systemic antimuscarinic and adds to the anticholinergic effect of inhaled glycopyrronium. This can increase dry mouth, constipation, urinary retention, blurred vision and confusion, particularly in older adults.
How serious is the interaction between Indacaterol-glycopyrronium and Oxybutynin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and urinary retention, and use the lowest effective oxybutynin dose. Consider a non-anticholinergic bladder option in older or susceptible patients.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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