Drug interactions
Indacaterol-glycopyrronium + Phenelzine
Severity: Major
Indacaterol-glycopyrronium and Phenelzine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can potentiate the cardiovascular effects of beta-2 agonists, leading to palpitations, tachycardia, hypertension and QT prolongation. Indacaterol labeling advises extreme caution during or within two weeks of MAOI therapy.
What this interaction means in plain words
Indacaterol-glycopyrronium and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol-glycopyrronium belongs to Respiratory; Phenelzine belongs to Central Nervous System.
Why it happens
MAO inhibition increases catecholamine levels and potentiates the sympathomimetic and cardiac effects of the beta-2 agonist.
What to do
Avoid the combination where possible, or monitor blood pressure, heart rate and ECG closely. Consider an alternative bronchodilator while the patient takes the MAOI.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Phenelzine?
MediHelp rates the interaction as major. Indacaterol-glycopyrronium and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. MAO inhibitors can potentiate the cardiovascular effects of beta-2 agonists, leading to palpitations, tachycardia, hypertension and QT prolongation. Indacaterol labeling advises extreme caution during or within two weeks of MAOI therapy.
How serious is the interaction between Indacaterol-glycopyrronium and Phenelzine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor blood pressure, heart rate and ECG closely. Consider an alternative bronchodilator while the patient takes the MAOI.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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