Drug interactions
Indacaterol-glycopyrronium + Promethazine
Severity: Moderate
Indacaterol-glycopyrronium and Promethazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promethazine is strongly anticholinergic and sedating, so it adds to the antimuscarinic effects of glycopyrronium. Adverse effects include urinary retention, constipation, blurred vision and confusion, especially in older adults.
What this interaction means in plain words
Indacaterol-glycopyrronium and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Promethazine belongs to Respiratory.
Why it happens
Additive antimuscarinic effects; promethazine may also contribute modest QT prolongation.
What to do
Monitor for anticholinergic toxicity and use the lowest effective promethazine dose. Prefer a less anticholinergic antiemetic or antihistamine in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Promethazine?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promethazine is strongly anticholinergic and sedating, so it adds to the antimuscarinic effects of glycopyrronium. Adverse effects include urinary retention, constipation, blurred vision and confusion, especially in older adults.
How serious is the interaction between Indacaterol-glycopyrronium and Promethazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and use the lowest effective promethazine dose. Prefer a less anticholinergic antiemetic or antihistamine in older patients.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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