Drug interactions
Indacaterol-glycopyrronium + Selpercatinib
Severity: Moderate
Indacaterol-glycopyrronium and Selpercatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib can prolong the QT interval, and indacaterol may add to repolarisation effects and hypokalemia. The combination may increase the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Indacaterol-glycopyrronium and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Selpercatinib belongs to Oncology.
Why it happens
Additive QT prolongation with possible beta-agonist induced hypokalemia.
What to do
Monitor ECG and keep potassium and magnesium normal. Reduce selpercatinib dose or interrupt therapy if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Selpercatinib
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Selpercatinib?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selpercatinib can prolong the QT interval, and indacaterol may add to repolarisation effects and hypokalemia. The combination may increase the risk of serious ventricular arrhythmia.
How serious is the interaction between Indacaterol-glycopyrronium and Selpercatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and keep potassium and magnesium normal. Reduce selpercatinib dose or interrupt therapy if QTc becomes markedly prolonged.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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