Drug interactions
Indacaterol-glycopyrronium + Tolterodine
Severity: Moderate
Indacaterol-glycopyrronium and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antimuscarinic agents, so combined use can add to dry mouth, constipation, blurred vision and urinary retention. This is usually manageable but more important in older adults.
What this interaction means in plain words
Indacaterol-glycopyrronium and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Tolterodine belongs to Genitourinary.
Why it happens
Additive antimuscarinic activity.
What to do
Monitor for anticholinergic effects, especially urinary retention and constipation. Reduce or stop one agent if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Tolterodine
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Tolterodine?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antimuscarinic agents, so combined use can add to dry mouth, constipation, blurred vision and urinary retention. This is usually manageable but more important in older adults.
How serious is the interaction between Indacaterol-glycopyrronium and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, especially urinary retention and constipation. Reduce or stop one agent if symptoms occur.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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