Drug interactions
Indacaterol inhaled + Metolazone
Severity: Moderate
Indacaterol inhaled and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol can lower serum potassium, and with non-potassium-sparing diuretics like metolazone the hypokalemia may be additive. ECG changes and arrhythmias are more likely when potassium is low.
What this interaction means in plain words
Indacaterol inhaled and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 agonist-driven intracellular potassium shift adds to renal potassium loss from metolazone.
What to do
Monitor serum potassium periodically, particularly in patients with heart disease, and correct hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Frequently asked questions
Can I take Indacaterol inhaled with Metolazone?
MediHelp rates the interaction as moderate. Indacaterol inhaled and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indacaterol can lower serum potassium, and with non-potassium-sparing diuretics like metolazone the hypokalemia may be additive. ECG changes and arrhythmias are more likely when potassium is low.
How serious is the interaction between Indacaterol inhaled and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically, particularly in patients with heart disease, and correct hypokalemia.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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