Drug interactions
Indacaterol inhaled + Ondansetron
Severity: Moderate
Indacaterol inhaled and Ondansetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol can cause QT prolongation at higher exposures, though inhaled doses give little effect, and ondansetron adds to QT effect. The combined risk is generally small in usual use but matters in patients with cardiac risk factors.
What this interaction means in plain words
Indacaterol inhaled and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT effects: beta-2 agonist-related repolarization changes and hypokalemia plus ondansetron hERG blockade.
What to do
Monitor the ECG and potassium in patients with existing QT risk factors. Avoid repeated ondansetron dosing in those patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Frequently asked questions
Can I take Indacaterol inhaled with Ondansetron?
MediHelp rates the interaction as moderate. Indacaterol inhaled and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indacaterol can cause QT prolongation at higher exposures, though inhaled doses give little effect, and ondansetron adds to QT effect. The combined risk is generally small in usual use but matters in patients with cardiac risk factors.
How serious is the interaction between Indacaterol inhaled and Ondansetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and potassium in patients with existing QT risk factors. Avoid repeated ondansetron dosing in those patients.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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