Drug interactions
Indacaterol inhaled + Ranolazine
Severity: Moderate
Indacaterol inhaled and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol can prolong QTc at high exposures and cause hypokalemia, and ranolazine also prolongs QTc. The combination may modestly increase arrhythmia risk.
What this interaction means in plain words
Indacaterol inhaled and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation, with beta-agonist-related hypokalemia as a contributing factor.
What to do
Monitor ECG in patients with cardiac risk factors and check potassium levels. Use indacaterol only at the labeled dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Indacaterol inhaled with Ranolazine?
MediHelp rates the interaction as moderate. Indacaterol inhaled and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indacaterol can prolong QTc at high exposures and cause hypokalemia, and ranolazine also prolongs QTc. The combination may modestly increase arrhythmia risk.
How serious is the interaction between Indacaterol inhaled and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac risk factors and check potassium levels. Use indacaterol only at the labeled dose.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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