Drug interactions
Indacaterol inhaled + Trimipramine
Severity: Moderate
Indacaterol inhaled and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of beta2-agonists such as indacaterol, including tachycardia, QT prolongation and arrhythmias. The risk is greatest in patients with existing cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Indacaterol inhaled and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac repolarization and adrenergic cardiovascular stimulation.
What to do
Monitor heart rate, rhythm and QTc, and correct hypokalemia. Consider an alternative bronchodilator if palpitations or ECG changes occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Indacaterol inhaled with Trimipramine?
MediHelp rates the interaction as moderate. Indacaterol inhaled and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of beta2-agonists such as indacaterol, including tachycardia, QT prolongation and arrhythmias. The risk is greatest in patients with existing cardiac disease or electrolyte disturbances.
How serious is the interaction between Indacaterol inhaled and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and QTc, and correct hypokalemia. Consider an alternative bronchodilator if palpitations or ECG changes occur.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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