Drug interactions
Indapamide + Insulin degludec-insulin aspart
Severity: Moderate
Indapamide and Insulin degludec-insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide, a thiazide-like diuretic, may raise blood glucose and blunt insulin effect. Its impact on glycemia is usually modest but can matter in poorly controlled diabetes.
What this interaction means in plain words
Indapamide and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Insulin degludec-insulin aspart belongs to Endocrine.
Why it happens
Diuretic-associated hypokalemia and impaired insulin secretion and sensitivity oppose the action of insulin.
What to do
Monitor blood glucose and potassium after starting or adjusting indapamide. Adjust the insulin dose if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Insulin degludec-insulin aspart?
MediHelp rates the interaction as moderate. Indapamide and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide, a thiazide-like diuretic, may raise blood glucose and blunt insulin effect. Its impact on glycemia is usually modest but can matter in poorly controlled diabetes.
How serious is the interaction between Indapamide and Insulin degludec-insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium after starting or adjusting indapamide. Adjust the insulin dose if control worsens.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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