Drug interactions
Indapamide + Ondansetron
Severity: Moderate
Indapamide and Ondansetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide may prolong the QT interval and, like other diuretics, can cause hypokalemia and hypomagnesemia. These changes increase the risk of torsades de pointes when ondansetron is added.
What this interaction means in plain words
Indapamide and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation, amplified by diuretic-induced hypokalemia and hypomagnesemia.
What to do
Check potassium and magnesium before and during treatment and correct deficits. Obtain an ECG in patients with cardiac disease or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Ondansetron?
MediHelp rates the interaction as moderate. Indapamide and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide may prolong the QT interval and, like other diuretics, can cause hypokalemia and hypomagnesemia. These changes increase the risk of torsades de pointes when ondansetron is added.
How serious is the interaction between Indapamide and Ondansetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium before and during treatment and correct deficits. Obtain an ECG in patients with cardiac disease or other QT-prolonging drugs.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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