Drug interactions
Indapamide + Ozanimod
Severity: Moderate
Indapamide and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and affect cardiac conduction, and indapamide may contribute to QT prolongation through electrolyte loss. Combined use may add to arrhythmia risk.
What this interaction means in plain words
Indapamide and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Ozanimod belongs to Central Nervous System.
Why it happens
Additive effects on cardiac rhythm: S1P-mediated bradycardia from ozanimod plus electrolyte-related QT prolongation from the diuretic.
What to do
Correct potassium and magnesium before starting ozanimod and monitor ECG and heart rate. Seek cardiology advice if the patient has other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Indapamide with Ozanimod?
MediHelp rates the interaction as moderate. Indapamide and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can slow heart rate and affect cardiac conduction, and indapamide may contribute to QT prolongation through electrolyte loss. Combined use may add to arrhythmia risk.
How serious is the interaction between Indapamide and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before starting ozanimod and monitor ECG and heart rate. Seek cardiology advice if the patient has other QT risk factors.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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