Drug interactions
Indapamide + Tiotropium-olodaterol
Severity: Moderate
Indapamide and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olodaterol can lower serum potassium, and indapamide is a thiazide-like diuretic that causes potassium loss and has been associated with QT prolongation. Together they may produce hypokalemia that predisposes to ventricular arrhythmias, especially in patients with heart disease.
What this interaction means in plain words
Indapamide and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive hypokalemia from beta2-agonist-driven intracellular potassium shift and diuretic renal potassium loss, with possible QT effects.
What to do
Check serum potassium and magnesium at baseline and periodically, and correct deficits. Consider an ECG in patients with cardiac disease or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Indapamide and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olodaterol can lower serum potassium, and indapamide is a thiazide-like diuretic that causes potassium loss and has been associated with QT prolongation. Together they may produce hypokalemia that predisposes to ventricular arrhythmias, especially in patients with heart disease.
How serious is the interaction between Indapamide and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium at baseline and periodically, and correct deficits. Consider an ECG in patients with cardiac disease or other QT-prolonging drugs.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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