Drug interactions
Indapamide + Vitamin d
Severity: Moderate
Indapamide and Vitamin d: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-type diuretics reduce urinary calcium excretion, so combining them with vitamin D or its analogs can raise serum calcium and occasionally cause hypercalcemia. The risk is higher with high vitamin D doses, calcium supplements or renal impairment.
What this interaction means in plain words
Indapamide and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Vitamin d belongs to Gastrointestinal Tract.
Why it happens
Indapamide increases distal tubular calcium reabsorption while vitamin D increases intestinal calcium absorption, producing additive rises in serum calcium.
What to do
Monitor serum calcium periodically, especially with high-dose vitamin D or calcium supplements. Reduce the vitamin D dose or stop the diuretic if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Vitamin d
Frequently asked questions
Can I take Indapamide with Vitamin d?
MediHelp rates the interaction as moderate. Indapamide and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide-type diuretics reduce urinary calcium excretion, so combining them with vitamin D or its analogs can raise serum calcium and occasionally cause hypercalcemia. The risk is higher with high vitamin D doses, calcium supplements or renal impairment.
How serious is the interaction between Indapamide and Vitamin d?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically, especially with high-dose vitamin D or calcium supplements. Reduce the vitamin D dose or stop the diuretic if hypercalcemia develops.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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